TEST: Philip & Sima Needleman Center for Autophagy Therapeutics & Research Symposium: Jan. 30, 2024
January 11, 2024
Highlighting the exciting work of founders of the Philip and Sima Needleman Center for Autophagy Therapeutics and Research, as well as speakers who are prominent leaders in the field.
Learn about exciting new ideas for how the autophagy pathway can be probed as an appealing and dynamic platform for development of new anti-aging therapies.
The Philip and Sima Needleman Center for Autophagy Therapeutics and Research at Washington University School of Medicine is dedicated to developing novel therapeutics that harness autophagy, a fundamental cellular pathway that has been implicated in age-dependent degeneration, cognitive decline, atherosclerosis, diabetes, obesity, infections, inflammatory diseases and cancer.
Tuesday, January 30, 2024 | 9 a.m. – 1 p.m.
EPNEC Auditorium, Washington University Medical Campus
Master of Ceremony: David H. Perlmutter, MD
9 – 9:15 a.m. | Welcome and Remarks
David H. Perlmutter, MD
Executive Vice Chancellor for Medical Affairs, Washington University
George and Carol Bauer Dean of the School of Medicine
Spencer T. and Ann W. Olin Distinguished Professor
Philip Needleman, PhD
Former Professor and Chairman of the Department of Pharmacology, Washington University
Member of the National Academy of Sciences
Former Chief Scientist and Head of R&D Monsanto/Searle/Pharmacia; Former Interim President of Donald Danforth Plant Science Center; Former Interim CEO of the St Louis Science Center
9:15 – 9:30 a.m. | Overview of the Field of Autophagy
David H. Perlmutter, MD
Executive Vice Chancellor for Medical Affairs, Washington University
George and Carol Bauer Dean of the School of Medicine
Spencer T. and Ann W. Olin Distinguished Professor
9:30 – 10:30 a.m. | Molecular Mechanisms and Pathophysiological Roles of Autophagy
Noboru Mizushima, PhD
Professor, Department of Physiology and Cell Biology, Tokyo Medical and Dental University
Professor, Department of Biochemistry and Molecular Biology,
Graduate School and Faculty of Medicine, The University of Tokyo
10:30 – 10:45 a.m. Break
10:45 – 11:30 a.m. | Rescuing Lysosomal Defects in Neurodegenerative Diseases
Celeste Karch, PhD
Professor of Psychiatry, Washington University
Biomarker Core Leader, Knight Alzheimer Disease Research Center (ADRC)
Scientific Director, Dominantly Inherited Alzheimer Network (DIAN)
Associate Director, Dominantly Inherited Alzheimer Network (DIAN)
11:30 a.m. – 12:15 p.m. | Inducing Hepatocyte Fasting-like Response to Treat Metabolic Disease
Brian DeBosch, MD, PhD
Associate Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition, Washington University
12:15 p.m. | Closing Remarks
David H. Perlmutter, MD
Executive Vice Chancellor for Medical Affairs, Washington University
George and Carol Bauer Dean of the School of Medicine
Spencer T. and Ann W. Olin Distinguished Professor